Inflammatory expression profiles in monocyte-to-macrophage differentiation in patients with systemic lupus erythematosus and relationship with atherosclerosis
Identifieur interne : 002693 ( Main/Exploration ); précédent : 002692; suivant : 002694Inflammatory expression profiles in monocyte-to-macrophage differentiation in patients with systemic lupus erythematosus and relationship with atherosclerosis
Auteurs : Benjamin D. Korman [États-Unis] ; Chiang-Ching Huang [États-Unis] ; Carly Skamra [États-Unis] ; Peggy Wu [États-Unis] ; Renee Koessler [États-Unis] ; David Yao [États-Unis] ; Qi Quan Huang [États-Unis] ; William Pearce [États-Unis] ; Kim Sutton-Tyrrell [États-Unis] ; George Kondos [États-Unis] ; Daniel Edmundowicz [États-Unis] ; Richard Pope [États-Unis] ; Rosalind Ramsey-Goldman [États-Unis]Source :
- Arthritis Research & Therapy [ 1478-6354 ] ; 2014.
Abstract
Our objectives were to examine mononuclear cell gene expression profiles in patients with systemic lupus erythematosus (SLE) and healthy controls and to compare subsets with and without atherosclerosis to determine which genes’ expression is related to atherosclerosis in SLE.
Monocytes were obtained from 20 patients with SLE and 16 healthy controls and were
Gene expression profiling was used to identify gene signatures that differentiated patients from controls and individuals with and without atherosclerosis. In monocytes, 9 out of 20 patients with SLE had an interferon-inducible signature compared with 2 out of 16 controls. By looking at gene expression during monocyte-to-macrophage differentiation, we identified pathways which were differentially regulated between SLE and controls and identified signatures based on relevant intracellular signaling molecules which could differentiate SLE patients with atherosclerosis from controls. Among patients with SLE, we used a previously defined 344-gene atherosclerosis signature in monocyte-to-macrophage differentiation to identify patient subgroups with and without atherosclerosis. Interestingly, this signature further classified patients on the basis of the presence of SLE disease activity and cardiovascular risk factors.
Many genes were differentially regulated during monocyte-to-macrophage differentiation in SLE patients compared with controls. The expression of these genes in mononuclear cells is important in the pathogenesis of SLE, and molecular profiling using gene expression can help stratify SLE patients who may be at risk for development of atherosclerosis.
Url:
DOI: 10.1186/ar4609
PubMed: 25011540
PubMed Central: 4227297
Affiliations:
- États-Unis
- Illinois, Pennsylvanie
- Chicago, Pittsburgh
- Université de Pittsburgh, Université de l'Illinois à Chicago
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Le document en format XML
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<front><div type="abstract" xml:lang="en"><sec><title>Introduction</title>
<p>Our objectives were to examine mononuclear cell gene expression profiles in patients with systemic lupus erythematosus (SLE) and healthy controls and to compare subsets with and without atherosclerosis to determine which genes’ expression is related to atherosclerosis in SLE.</p>
</sec>
<sec><title>Methods</title>
<p>Monocytes were obtained from 20 patients with SLE and 16 healthy controls and were <italic>in vitro</italic>
-differentiated into macrophages. Subjects also underwent laboratory and imaging studies to evaluate for subclinical atherosclerosis. Whole-genome RNA expression microarray was performed, and gene expression was examined.</p>
</sec>
<sec><title>Results</title>
<p>Gene expression profiling was used to identify gene signatures that differentiated patients from controls and individuals with and without atherosclerosis. In monocytes, 9 out of 20 patients with SLE had an interferon-inducible signature compared with 2 out of 16 controls. By looking at gene expression during monocyte-to-macrophage differentiation, we identified pathways which were differentially regulated between SLE and controls and identified signatures based on relevant intracellular signaling molecules which could differentiate SLE patients with atherosclerosis from controls. Among patients with SLE, we used a previously defined 344-gene atherosclerosis signature in monocyte-to-macrophage differentiation to identify patient subgroups with and without atherosclerosis. Interestingly, this signature further classified patients on the basis of the presence of SLE disease activity and cardiovascular risk factors.</p>
</sec>
<sec><title>Conclusions</title>
<p>Many genes were differentially regulated during monocyte-to-macrophage differentiation in SLE patients compared with controls. The expression of these genes in mononuclear cells is important in the pathogenesis of SLE, and molecular profiling using gene expression can help stratify SLE patients who may be at risk for development of atherosclerosis.</p>
</sec>
</div>
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<author><name sortKey="Abrahamowicz, M" uniqKey="Abrahamowicz M">M Abrahamowicz</name>
</author>
<author><name sortKey="Grodzicky, T" uniqKey="Grodzicky T">T Grodzicky</name>
</author>
<author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name>
</author>
<author><name sortKey="Panaritis, C" uniqKey="Panaritis C">C Panaritis</name>
</author>
<author><name sortKey="Du Berger, R" uniqKey="Du Berger R">R du Berger</name>
</author>
<author><name sortKey="Cote, R" uniqKey="Cote R">R Cote</name>
</author>
<author><name sortKey="Grover, Sa" uniqKey="Grover S">SA Grover</name>
</author>
<author><name sortKey="Fortin, Pr" uniqKey="Fortin P">PR Fortin</name>
</author>
<author><name sortKey="Clarke, Ae" uniqKey="Clarke A">AE Clarke</name>
</author>
<author><name sortKey="Senecal, Jl" uniqKey="Senecal J">JL Senécal</name>
</author>
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</author>
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</author>
<author><name sortKey="Rairie, Je" uniqKey="Rairie J">JE Rairie</name>
</author>
<author><name sortKey="Conte, Cg" uniqKey="Conte C">CG Conte</name>
</author>
<author><name sortKey="Medsger, Ta" uniqKey="Medsger T">TA Medsger</name>
</author>
<author><name sortKey="Jansen Mcwilliams, L" uniqKey="Jansen Mcwilliams L">L Jansen-McWilliams</name>
</author>
<author><name sortKey="D Gostino, Rb" uniqKey="D Gostino R">RB D’Agostino</name>
</author>
<author><name sortKey="Kuller, Lh" uniqKey="Kuller L">LH Kuller</name>
</author>
</analytic>
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</author>
<author><name sortKey="Perez Gutthann, S" uniqKey="Perez Gutthann S">S Perez-Gutthann</name>
</author>
<author><name sortKey="Spence, D" uniqKey="Spence D">D Spence</name>
</author>
<author><name sortKey="Hochberg, Mc" uniqKey="Hochberg M">MC Hochberg</name>
</author>
</analytic>
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<biblStruct><analytic><author><name sortKey="Petri, M" uniqKey="Petri M">M Petri</name>
</author>
<author><name sortKey="Spence, D" uniqKey="Spence D">D Spence</name>
</author>
<author><name sortKey="Bone, Lr" uniqKey="Bone L">LR Bone</name>
</author>
<author><name sortKey="Hochberg, Mc" uniqKey="Hochberg M">MC Hochberg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Roman, Mj" uniqKey="Roman M">MJ Roman</name>
</author>
<author><name sortKey="Shanker, Ba" uniqKey="Shanker B">BA Shanker</name>
</author>
<author><name sortKey="Davis, A" uniqKey="Davis A">A Davis</name>
</author>
<author><name sortKey="Lockshin, Md" uniqKey="Lockshin M">MD Lockshin</name>
</author>
<author><name sortKey="Sammaritano, L" uniqKey="Sammaritano L">L Sammaritano</name>
</author>
<author><name sortKey="Simantov, R" uniqKey="Simantov R">R Simantov</name>
</author>
<author><name sortKey="Crow, Mk" uniqKey="Crow M">MK Crow</name>
</author>
<author><name sortKey="Schwartz, Je" uniqKey="Schwartz J">JE Schwartz</name>
</author>
<author><name sortKey="Paget, Sa" uniqKey="Paget S">SA Paget</name>
</author>
<author><name sortKey="Devereux, Rb" uniqKey="Devereux R">RB Devereux</name>
</author>
<author><name sortKey="Salmon, Je" uniqKey="Salmon J">JE Salmon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, J" uniqKey="Li J">J Li</name>
</author>
<author><name sortKey="Fu, Q" uniqKey="Fu Q">Q Fu</name>
</author>
<author><name sortKey="Cui, H" uniqKey="Cui H">H Cui</name>
</author>
<author><name sortKey="Qu, B" uniqKey="Qu B">B Qu</name>
</author>
<author><name sortKey="Pan, W" uniqKey="Pan W">W Pan</name>
</author>
<author><name sortKey="Shen, N" uniqKey="Shen N">N Shen</name>
</author>
<author><name sortKey="Bao, C" uniqKey="Bao C">C Bao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mcmahon, M" uniqKey="Mcmahon M">M McMahon</name>
</author>
<author><name sortKey="Hahn, Bh" uniqKey="Hahn B">BH Hahn</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Libby, P" uniqKey="Libby P">P Libby</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Woollard, Kj" uniqKey="Woollard K">KJ Woollard</name>
</author>
<author><name sortKey="Geissmann, F" uniqKey="Geissmann F">F Geissmann</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name>
</author>
<author><name sortKey="Lee, Py" uniqKey="Lee P">PY Lee</name>
</author>
<author><name sortKey="Reeves, Wh" uniqKey="Reeves W">WH Reeves</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Crow, Mk" uniqKey="Crow M">MK Crow</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bennett, L" uniqKey="Bennett L">L Bennett</name>
</author>
<author><name sortKey="Palucka, Ak" uniqKey="Palucka A">AK Palucka</name>
</author>
<author><name sortKey="Arce, E" uniqKey="Arce E">E Arce</name>
</author>
<author><name sortKey="Cantrell, V" uniqKey="Cantrell V">V Cantrell</name>
</author>
<author><name sortKey="Borvak, J" uniqKey="Borvak J">J Borvak</name>
</author>
<author><name sortKey="Banchereau, J" uniqKey="Banchereau J">J Banchereau</name>
</author>
<author><name sortKey="Pascual, V" uniqKey="Pascual V">V Pascual</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pascual, V" uniqKey="Pascual V">V Pascual</name>
</author>
<author><name sortKey="Farkas, L" uniqKey="Farkas L">L Farkas</name>
</author>
<author><name sortKey="Banchereau, J" uniqKey="Banchereau J">J Banchereau</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Baechler, Ec" uniqKey="Baechler E">EC Baechler</name>
</author>
<author><name sortKey="Batliwalla, Fm" uniqKey="Batliwalla F">FM Batliwalla</name>
</author>
<author><name sortKey="Karypis, G" uniqKey="Karypis G">G Karypis</name>
</author>
<author><name sortKey="Gaffney, Pm" uniqKey="Gaffney P">PM Gaffney</name>
</author>
<author><name sortKey="Ortmann, Wa" uniqKey="Ortmann W">WA Ortmann</name>
</author>
<author><name sortKey="Espe, Kj" uniqKey="Espe K">KJ Espe</name>
</author>
<author><name sortKey="Shark, Kb" uniqKey="Shark K">KB Shark</name>
</author>
<author><name sortKey="Grande, Wj" uniqKey="Grande W">WJ Grande</name>
</author>
<author><name sortKey="Hughes, Km" uniqKey="Hughes K">KM Hughes</name>
</author>
<author><name sortKey="Kapur, V" uniqKey="Kapur V">V Kapur</name>
</author>
<author><name sortKey="Gregersen, Pk" uniqKey="Gregersen P">PK Gregersen</name>
</author>
<author><name sortKey="Behrens, Tw" uniqKey="Behrens T">TW Behrens</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sinnaeve, Pr" uniqKey="Sinnaeve P">PR Sinnaeve</name>
</author>
<author><name sortKey="Donahue, Mp" uniqKey="Donahue M">MP Donahue</name>
</author>
<author><name sortKey="Grass, P" uniqKey="Grass P">P Grass</name>
</author>
<author><name sortKey="Seo, D" uniqKey="Seo D">D Seo</name>
</author>
<author><name sortKey="Vonderscher, J" uniqKey="Vonderscher J">J Vonderscher</name>
</author>
<author><name sortKey="Chibout, Sd" uniqKey="Chibout S">SD Chibout</name>
</author>
<author><name sortKey="Kraus, We" uniqKey="Kraus W">WE Kraus</name>
</author>
<author><name sortKey="Sketch, M" uniqKey="Sketch M">M Sketch</name>
</author>
<author><name sortKey="Nelson, C" uniqKey="Nelson C">C Nelson</name>
</author>
<author><name sortKey="Ginsburg, Gs" uniqKey="Ginsburg G">GS Ginsburg</name>
</author>
<author><name sortKey="Goldschmidt Clermont, Pj" uniqKey="Goldschmidt Clermont P">PJ Goldschmidt-Clermont</name>
</author>
<author><name sortKey="Granger, Cb" uniqKey="Granger C">CB Granger</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wingrove, Ja" uniqKey="Wingrove J">JA Wingrove</name>
</author>
<author><name sortKey="Daniels, Se" uniqKey="Daniels S">SE Daniels</name>
</author>
<author><name sortKey="Sehnert, Aj" uniqKey="Sehnert A">AJ Sehnert</name>
</author>
<author><name sortKey="Tingley, W" uniqKey="Tingley W">W Tingley</name>
</author>
<author><name sortKey="Elashoff, Mr" uniqKey="Elashoff M">MR Elashoff</name>
</author>
<author><name sortKey="Rosenberg, S" uniqKey="Rosenberg S">S Rosenberg</name>
</author>
<author><name sortKey="Buellesfeld, L" uniqKey="Buellesfeld L">L Buellesfeld</name>
</author>
<author><name sortKey="Grube, E" uniqKey="Grube E">E Grube</name>
</author>
<author><name sortKey="Newby, Lk" uniqKey="Newby L">LK Newby</name>
</author>
<author><name sortKey="Ginsburg, Gs" uniqKey="Ginsburg G">GS Ginsburg</name>
</author>
<author><name sortKey="Kraus, We" uniqKey="Kraus W">WE Kraus</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Charchar, Fj" uniqKey="Charchar F">FJ Charchar</name>
</author>
<author><name sortKey="Bloomer, Ld" uniqKey="Bloomer L">LD Bloomer</name>
</author>
<author><name sortKey="Barnes, Ta" uniqKey="Barnes T">TA Barnes</name>
</author>
<author><name sortKey="Cowley, Mj" uniqKey="Cowley M">MJ Cowley</name>
</author>
<author><name sortKey="Nelson, Cp" uniqKey="Nelson C">CP Nelson</name>
</author>
<author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name>
</author>
<author><name sortKey="Denniff, M" uniqKey="Denniff M">M Denniff</name>
</author>
<author><name sortKey="Debiec, R" uniqKey="Debiec R">R Debiec</name>
</author>
<author><name sortKey="Christofidou, P" uniqKey="Christofidou P">P Christofidou</name>
</author>
<author><name sortKey="Nankervis, S" uniqKey="Nankervis S">S Nankervis</name>
</author>
<author><name sortKey="Dominiczak, Af" uniqKey="Dominiczak A">AF Dominiczak</name>
</author>
<author><name sortKey="Bani Mustafa, A" uniqKey="Bani Mustafa A">A Bani-Mustafa</name>
</author>
<author><name sortKey="Balmforth, Aj" uniqKey="Balmforth A">AJ Balmforth</name>
</author>
<author><name sortKey="Hall, As" uniqKey="Hall A">AS Hall</name>
</author>
<author><name sortKey="Erdmann, J" uniqKey="Erdmann J">J Erdmann</name>
</author>
<author><name sortKey="Cambien, F" uniqKey="Cambien F">F Cambien</name>
</author>
<author><name sortKey="Deloukas, P" uniqKey="Deloukas P">P Deloukas</name>
</author>
<author><name sortKey="Hengstenberg, C" uniqKey="Hengstenberg C">C Hengstenberg</name>
</author>
<author><name sortKey="Packard, C" uniqKey="Packard C">C Packard</name>
</author>
<author><name sortKey="Schunkert, H" uniqKey="Schunkert H">H Schunkert</name>
</author>
<author><name sortKey="Ouwehand, Wh" uniqKey="Ouwehand W">WH Ouwehand</name>
</author>
<author><name sortKey="Ford, I" uniqKey="Ford I">I Ford</name>
</author>
<author><name sortKey="Goodall, Ah" uniqKey="Goodall A">AH Goodall</name>
</author>
<author><name sortKey="Jobling, Ma" uniqKey="Jobling M">MA Jobling</name>
</author>
<author><name sortKey="Samani, Nj" uniqKey="Samani N">NJ Samani</name>
</author>
<author><name sortKey="Tomaszewski, M" uniqKey="Tomaszewski M">M Tomaszewski</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Huang, Cc" uniqKey="Huang C">CC Huang</name>
</author>
<author><name sortKey="Liu, K" uniqKey="Liu K">K Liu</name>
</author>
<author><name sortKey="Pope, Rm" uniqKey="Pope R">RM Pope</name>
</author>
<author><name sortKey="Du, P" uniqKey="Du P">P Du</name>
</author>
<author><name sortKey="Lin, S" uniqKey="Lin S">S Lin</name>
</author>
<author><name sortKey="Rajamannan, Nm" uniqKey="Rajamannan N">NM Rajamannan</name>
</author>
<author><name sortKey="Huang, Qq" uniqKey="Huang Q">QQ Huang</name>
</author>
<author><name sortKey="Jafari, N" uniqKey="Jafari N">N Jafari</name>
</author>
<author><name sortKey="Burke, Gl" uniqKey="Burke G">GL Burke</name>
</author>
<author><name sortKey="Post, W" uniqKey="Post W">W Post</name>
</author>
<author><name sortKey="Watson, Ke" uniqKey="Watson K">KE Watson</name>
</author>
<author><name sortKey="Johnson, C" uniqKey="Johnson C">C Johnson</name>
</author>
<author><name sortKey="Daviglus, Ml" uniqKey="Daviglus M">ML Daviglus</name>
</author>
<author><name sortKey="Lloyd Jones, Dm" uniqKey="Lloyd Jones D">DM Lloyd-Jones</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, H" uniqKey="Liu H">H Liu</name>
</author>
<author><name sortKey="Shi, B" uniqKey="Shi B">B Shi</name>
</author>
<author><name sortKey="Huang, Cc" uniqKey="Huang C">CC Huang</name>
</author>
<author><name sortKey="Eksarko, P" uniqKey="Eksarko P">P Eksarko</name>
</author>
<author><name sortKey="Pope, Rm" uniqKey="Pope R">RM Pope</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Martinez, Fo" uniqKey="Martinez F">FO Martinez</name>
</author>
<author><name sortKey="Gordon, S" uniqKey="Gordon S">S Gordon</name>
</author>
<author><name sortKey="Locati, M" uniqKey="Locati M">M Locati</name>
</author>
<author><name sortKey="Mantovani, A" uniqKey="Mantovani A">A Mantovani</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rhew, Ey" uniqKey="Rhew E">EY Rhew</name>
</author>
<author><name sortKey="Lee, C" uniqKey="Lee C">C Lee</name>
</author>
<author><name sortKey="Eksarko, P" uniqKey="Eksarko P">P Eksarko</name>
</author>
<author><name sortKey="Dyer, Ar" uniqKey="Dyer A">AR Dyer</name>
</author>
<author><name sortKey="Tily, H" uniqKey="Tily H">H Tily</name>
</author>
<author><name sortKey="Spies, S" uniqKey="Spies S">S Spies</name>
</author>
<author><name sortKey="Pope, Rm" uniqKey="Pope R">RM Pope</name>
</author>
<author><name sortKey="Ramsey Goldman, R" uniqKey="Ramsey Goldman R">R Ramsey-Goldman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bild, De" uniqKey="Bild D">DE Bild</name>
</author>
<author><name sortKey="Bluemke, Da" uniqKey="Bluemke D">DA Bluemke</name>
</author>
<author><name sortKey="Burke, Gl" uniqKey="Burke G">GL Burke</name>
</author>
<author><name sortKey="Detrano, R" uniqKey="Detrano R">R Detrano</name>
</author>
<author><name sortKey="Diez Roux, Av" uniqKey="Diez Roux A">AV Diez Roux</name>
</author>
<author><name sortKey="Folsom, Ar" uniqKey="Folsom A">AR Folsom</name>
</author>
<author><name sortKey="Greenland, P" uniqKey="Greenland P">P Greenland</name>
</author>
<author><name sortKey="Jacob, Dr" uniqKey="Jacob D">DR Jacob</name>
</author>
<author><name sortKey="Kronmal, R" uniqKey="Kronmal R">R Kronmal</name>
</author>
<author><name sortKey="Liu, K" uniqKey="Liu K">K Liu</name>
</author>
<author><name sortKey="Nelson, Jc" uniqKey="Nelson J">JC Nelson</name>
</author>
<author><name sortKey="O Eary, D" uniqKey="O Eary D">D O’Leary</name>
</author>
<author><name sortKey="Saad, Mf" uniqKey="Saad M">MF Saad</name>
</author>
<author><name sortKey="Shea, S" uniqKey="Shea S">S Shea</name>
</author>
<author><name sortKey="Szklo, M" uniqKey="Szklo M">M Szklo</name>
</author>
<author><name sortKey="Tracy, Rp" uniqKey="Tracy R">RP Tracy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gladman, D" uniqKey="Gladman D">D Gladman</name>
</author>
<author><name sortKey="Ginzler, E" uniqKey="Ginzler E">E Ginzler</name>
</author>
<author><name sortKey="Goldsmith, C" uniqKey="Goldsmith C">C Goldsmith</name>
</author>
<author><name sortKey="Fortin, P" uniqKey="Fortin P">P Fortin</name>
</author>
<author><name sortKey="Liang, M" uniqKey="Liang M">M Liang</name>
</author>
<author><name sortKey="Urowitz, M" uniqKey="Urowitz M">M Urowitz</name>
</author>
<author><name sortKey="Bacon, P" uniqKey="Bacon P">P Bacon</name>
</author>
<author><name sortKey="Bombardieri, S" uniqKey="Bombardieri S">S Bombardieri</name>
</author>
<author><name sortKey="Hanly, J" uniqKey="Hanly J">J Hanly</name>
</author>
<author><name sortKey="Hay, E" uniqKey="Hay E">E Hay</name>
</author>
<author><name sortKey="Isenberg, D" uniqKey="Isenberg D">D Isenberg</name>
</author>
<author><name sortKey="Jones, J" uniqKey="Jones J">J Jones</name>
</author>
<author><name sortKey="Nived, O" uniqKey="Nived O">O Nived</name>
</author>
<author><name sortKey="Petri, M" uniqKey="Petri M">M Petri</name>
</author>
<author><name sortKey="Richter, M" uniqKey="Richter M">M Richter</name>
</author>
<author><name sortKey="Sanchez Guerrero, J" uniqKey="Sanchez Guerrero J">J Sanchez-Guerrero</name>
</author>
<author><name sortKey="Snaith, M" uniqKey="Snaith M">M Snaith</name>
</author>
<author><name sortKey="Sturfelt, G" uniqKey="Sturfelt G">G Sturfelt</name>
</author>
<author><name sortKey="Symmons, D" uniqKey="Symmons D">D Symmons</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gladman, Dd" uniqKey="Gladman D">DD Gladman</name>
</author>
<author><name sortKey="Ibanez, D" uniqKey="Ibanez D">D Ibanez</name>
</author>
<author><name sortKey="Urowitz, Mb" uniqKey="Urowitz M">MB Urowitz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Budoff, Mj" uniqKey="Budoff M">MJ Budoff</name>
</author>
<author><name sortKey="Mcclelland, Rl" uniqKey="Mcclelland R">RL McClelland</name>
</author>
<author><name sortKey="Nasir, K" uniqKey="Nasir K">K Nasir</name>
</author>
<author><name sortKey="Greenland, P" uniqKey="Greenland P">P Greenland</name>
</author>
<author><name sortKey="Kronmal, Ra" uniqKey="Kronmal R">RA Kronmal</name>
</author>
<author><name sortKey="Kondos, Gt" uniqKey="Kondos G">GT Kondos</name>
</author>
<author><name sortKey="Shea, S" uniqKey="Shea S">S Shea</name>
</author>
<author><name sortKey="Lima, Ja" uniqKey="Lima J">JA Lima</name>
</author>
<author><name sortKey="Blumenthal, Rs" uniqKey="Blumenthal R">RS Blumenthal</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Detrano, Rc" uniqKey="Detrano R">RC Detrano</name>
</author>
<author><name sortKey="Anderson, M" uniqKey="Anderson M">M Anderson</name>
</author>
<author><name sortKey="Nelson, J" uniqKey="Nelson J">J Nelson</name>
</author>
<author><name sortKey="Wong, Nd" uniqKey="Wong N">ND Wong</name>
</author>
<author><name sortKey="Carr, Jj" uniqKey="Carr J">JJ Carr</name>
</author>
<author><name sortKey="Mcnitt Gray, M" uniqKey="Mcnitt Gray M">M McNitt-Gray</name>
</author>
<author><name sortKey="Bild, De" uniqKey="Bild D">DE Bild</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Thompson, Ts Tk" uniqKey="Thompson T">TS-TK Thompson</name>
</author>
<author><name sortKey="Wildman, R" uniqKey="Wildman R">R Wildman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Johnson, We" uniqKey="Johnson W">WE Johnson</name>
</author>
<author><name sortKey="Li, C" uniqKey="Li C">C Li</name>
</author>
<author><name sortKey="Rabinovic, A" uniqKey="Rabinovic A">A Rabinovic</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Li, X" uniqKey="Li X">X Li</name>
</author>
<author><name sortKey="Tjwa, M" uniqKey="Tjwa M">M Tjwa</name>
</author>
<author><name sortKey="Van Hove, I" uniqKey="Van Hove I">I Van Hove</name>
</author>
<author><name sortKey="Enholm, B" uniqKey="Enholm B">B Enholm</name>
</author>
<author><name sortKey="Neven, E" uniqKey="Neven E">E Neven</name>
</author>
<author><name sortKey="Paavonen, K" uniqKey="Paavonen K">K Paavonen</name>
</author>
<author><name sortKey="Jeltsch, M" uniqKey="Jeltsch M">M Jeltsch</name>
</author>
<author><name sortKey="Juan, Td" uniqKey="Juan T">TD Juan</name>
</author>
<author><name sortKey="Sievers, Re" uniqKey="Sievers R">RE Sievers</name>
</author>
<author><name sortKey="Chorianopoulos, E" uniqKey="Chorianopoulos E">E Chorianopoulos</name>
</author>
<author><name sortKey="Wada, H" uniqKey="Wada H">H Wada</name>
</author>
<author><name sortKey="Van Wildemeersch, M" uniqKey="Van Wildemeersch M">M van Wildemeersch</name>
</author>
<author><name sortKey="Noel, A" uniqKey="Noel A">A Noel</name>
</author>
<author><name sortKey="Foidart, Jm" uniqKey="Foidart J">JM Foidart</name>
</author>
<author><name sortKey="Springer, Ml" uniqKey="Springer M">ML Springer</name>
</author>
<author><name sortKey="Von Degenfeld, G" uniqKey="Von Degenfeld G">G von Degenfeld</name>
</author>
<author><name sortKey="Dewerchin, M" uniqKey="Dewerchin M">M Dewerchin</name>
</author>
<author><name sortKey="Blau, Hm" uniqKey="Blau H">HM Blau</name>
</author>
<author><name sortKey="Alitalo, K" uniqKey="Alitalo K">K Alitalo</name>
</author>
<author><name sortKey="Eriksson, U" uniqKey="Eriksson U">U Eriksson</name>
</author>
<author><name sortKey="Carmeliet, P" uniqKey="Carmeliet P">P Carmeliet</name>
</author>
<author><name sortKey="Moons, L" uniqKey="Moons L">L Moons</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Neyen, C" uniqKey="Neyen C">C Neyen</name>
</author>
<author><name sortKey="Pluddemann, A" uniqKey="Pluddemann A">A Pluddemann</name>
</author>
<author><name sortKey="Roversi, P" uniqKey="Roversi P">P Roversi</name>
</author>
<author><name sortKey="Thomas, B" uniqKey="Thomas B">B Thomas</name>
</author>
<author><name sortKey="Cai, L" uniqKey="Cai L">L Cai</name>
</author>
<author><name sortKey="Van Der Westhuyzen, Dr" uniqKey="Van Der Westhuyzen D">DR van der Westhuyzen</name>
</author>
<author><name sortKey="Sim, Rb" uniqKey="Sim R">RB Sim</name>
</author>
<author><name sortKey="Gordon, S" uniqKey="Gordon S">S Gordon</name>
</author>
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<biblStruct><analytic><author><name sortKey="O Ullivan, La" uniqKey="O Ullivan L">LA O’Sullivan</name>
</author>
<author><name sortKey="Liongue, C" uniqKey="Liongue C">C Liongue</name>
</author>
<author><name sortKey="Lewis, Rs" uniqKey="Lewis R">RS Lewis</name>
</author>
<author><name sortKey="Stephenson, Se" uniqKey="Stephenson S">SE Stephenson</name>
</author>
<author><name sortKey="Ward, Ac" uniqKey="Ward A">AC Ward</name>
</author>
</analytic>
</biblStruct>
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</author>
<author><name sortKey="Gijbels, Mj" uniqKey="Gijbels M">MJ Gijbels</name>
</author>
<author><name sortKey="Van Der Velden, S" uniqKey="Van Der Velden S">S van der Velden</name>
</author>
<author><name sortKey="Manca, M" uniqKey="Manca M">M Manca</name>
</author>
<author><name sortKey="Van Der Loos, Cm" uniqKey="Van Der Loos C">CM van der Loos</name>
</author>
<author><name sortKey="Biessen, Ea" uniqKey="Biessen E">EA Biessen</name>
</author>
<author><name sortKey="Daemen, Mj" uniqKey="Daemen M">MJ Daemen</name>
</author>
<author><name sortKey="Lutgens, E" uniqKey="Lutgens E">E Lutgens</name>
</author>
<author><name sortKey="De Winther, Mp" uniqKey="De Winther M">MP de Winther</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kleemann, R" uniqKey="Kleemann R">R Kleemann</name>
</author>
<author><name sortKey="Bureeva, S" uniqKey="Bureeva S">S Bureeva</name>
</author>
<author><name sortKey="Perlina, A" uniqKey="Perlina A">A Perlina</name>
</author>
<author><name sortKey="Kaput, J" uniqKey="Kaput J">J Kaput</name>
</author>
<author><name sortKey="Verschuren, L" uniqKey="Verschuren L">L Verschuren</name>
</author>
<author><name sortKey="Wielinga, Py" uniqKey="Wielinga P">PY Wielinga</name>
</author>
<author><name sortKey="Hurt Camejo, E" uniqKey="Hurt Camejo E">E Hurt-Camejo</name>
</author>
<author><name sortKey="Nikolsky, Y" uniqKey="Nikolsky Y">Y Nikolsky</name>
</author>
<author><name sortKey="Van Ommen, B" uniqKey="Van Ommen B">B van Ommen</name>
</author>
<author><name sortKey="Kooistra, T" uniqKey="Kooistra T">T Kooistra</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Illinois</li>
<li>Pennsylvanie</li>
</region>
<settlement><li>Chicago</li>
<li>Pittsburgh</li>
</settlement>
<orgName><li>Université de Pittsburgh</li>
<li>Université de l'Illinois à Chicago</li>
</orgName>
</list>
<tree><country name="États-Unis"><region name="Illinois"><name sortKey="Korman, Benjamin D" sort="Korman, Benjamin D" uniqKey="Korman B" first="Benjamin D" last="Korman">Benjamin D. Korman</name>
</region>
<name sortKey="Edmundowicz, Daniel" sort="Edmundowicz, Daniel" uniqKey="Edmundowicz D" first="Daniel" last="Edmundowicz">Daniel Edmundowicz</name>
<name sortKey="Huang, Chiang Ching" sort="Huang, Chiang Ching" uniqKey="Huang C" first="Chiang-Ching" last="Huang">Chiang-Ching Huang</name>
<name sortKey="Huang, Qi Quan" sort="Huang, Qi Quan" uniqKey="Huang Q" first="Qi Quan" last="Huang">Qi Quan Huang</name>
<name sortKey="Koessler, Renee" sort="Koessler, Renee" uniqKey="Koessler R" first="Renee" last="Koessler">Renee Koessler</name>
<name sortKey="Kondos, George" sort="Kondos, George" uniqKey="Kondos G" first="George" last="Kondos">George Kondos</name>
<name sortKey="Pearce, William" sort="Pearce, William" uniqKey="Pearce W" first="William" last="Pearce">William Pearce</name>
<name sortKey="Pope, Richard" sort="Pope, Richard" uniqKey="Pope R" first="Richard" last="Pope">Richard Pope</name>
<name sortKey="Ramsey Goldman, Rosalind" sort="Ramsey Goldman, Rosalind" uniqKey="Ramsey Goldman R" first="Rosalind" last="Ramsey-Goldman">Rosalind Ramsey-Goldman</name>
<name sortKey="Skamra, Carly" sort="Skamra, Carly" uniqKey="Skamra C" first="Carly" last="Skamra">Carly Skamra</name>
<name sortKey="Sutton Tyrrell, Kim" sort="Sutton Tyrrell, Kim" uniqKey="Sutton Tyrrell K" first="Kim" last="Sutton-Tyrrell">Kim Sutton-Tyrrell</name>
<name sortKey="Wu, Peggy" sort="Wu, Peggy" uniqKey="Wu P" first="Peggy" last="Wu">Peggy Wu</name>
<name sortKey="Yao, David" sort="Yao, David" uniqKey="Yao D" first="David" last="Yao">David Yao</name>
</country>
</tree>
</affiliations>
</record>
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